1887
  1. Home
  2. Eurosurveillance
  3. Volume 28, Issue 42, 19/Oct/2023
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

We report cases of mammalian infection with highly pathogenic avian influenza (HPAI) virus A(H5N1) clade 2.3.4.4b in Northern Ireland. Two common gulls () and two red fox kits (), were found dead in close vicinity. Comparison of viral whole genome sequences obtained from the animals identified a novel mammalian adaptation, PB2-M535I. Analysis of genetic sequences from other recent mammalian infections shows that this mutation has arisen on at least five occasions in three European countries since April 2023.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2023.28.42.2300526
2023-10-19
2024-11-15
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.42.2300526
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/28/42/eurosurv-28-42-1.html?itemId=/content/10.2807/1560-7917.ES.2023.28.42.2300526&mimeType=html&fmt=ahah

References

  1. Adlhoch C, Fusaro A, Gonzales JL, Kuiken T, Melidou A, Mirinavičiūtė G, et al. Avian influenza overview April - June 2023. EFSA J. 2023;21(7):e08191. PMID: 37485254 
  2. Adlhoch C, Baldinelli F, Fusaro A, Terregino C. Avian influenza, a new threat to public health in Europe? Clin Microbiol Infect. 2022;28(2):149-51.  https://doi.org/10.1016/j.cmi.2021.11.005  PMID: 34763057 
  3. Nagy A, Černíková L, Kunteová K, Dirbáková Z, Thomas SS, Slomka MJ, et al. A universal RT-qPCR assay for "One Health" detection of influenza A viruses. PLoS One. 2021;16(1):e0244669.  https://doi.org/10.1371/journal.pone.0244669  PMID: 33471840 
  4. James J, Seekings AH, Skinner P, Purchase K, Mahmood S, Brown IH, et al. Rapid and sensitive detection of high pathogenicity Eurasian clade 2.3.4.4b avian influenza viruses in wild birds and poultry. J Virol Methods. 2022;301:114454.  https://doi.org/10.1016/j.jviromet.2022.114454  PMID: 34998830 
  5. Hoffmann B, Hoffmann D, Henritzi D, Beer M, Harder TC. Riems influenza a typing array (RITA): An RT-qPCR-based low density array for subtyping avian and mammalian influenza a viruses. Sci Rep. 2016;6(1):27211.  https://doi.org/10.1038/srep27211  PMID: 27256976 
  6. Cronk BD, Caserta LC, Laverack M, Gerdes RS, Hynes K, Hopf CR, et al. Infection and tissue distribution of highly pathogenic avian influenza A type H5N1 (clade 2.3.4.4b) in red fox kits (Vulpes vulpes). Emerg Microbes Infect. 2023;12(2):2249554.  https://doi.org/10.1080/22221751.2023.2249554  PMID: 37589241 
  7. Zhou B, Donnelly ME, Scholes DT, St George K, Hatta M, Kawaoka Y, et al. Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and Swine origin human influenza a viruses. J Virol. 2009;83(19):10309-13.  https://doi.org/10.1128/JVI.01109-09  PMID: 19605485 
  8. Suttie A, Deng Y-M, Greenhill AR, Dussart P, Horwood PF, Karlsson EA. Inventory of molecular markers affecting biological characteristics of avian influenza A viruses. Virus Genes. 2019;55(6):739-68.  https://doi.org/10.1007/s11262-019-01700-z  PMID: 31428925 
  9. Domańska-Blicharz K, Świętoń E, Świątalska A, Monne I, Fusaro A, Tarasiuk K, et al. Outbreak of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus in cats, Poland, June to July 2023. Euro Surveill. 2023;28(31):2300366.  https://doi.org/10.2807/1560-7917.ES.2023.28.31.2300366  PMID: 37535474 
  10. Song W, Wang P, Mok BW-Y, Lau S-Y, Huang X, Wu W-L, et al. The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication. Nat Commun. 2014;5(1):5509.  https://doi.org/10.1038/ncomms6509  PMID: 25409547 
  11. Chen G-W, Kuo S-M, Yang S-L, Gong Y-N, Hsiao M-R, Liu Y-C, et al. Genomic signatures for Avian H7N9 viruses adapting to humans. PLoS One. 2016;11(2):e0148432.  https://doi.org/10.1371/journal.pone.0148432  PMID: 26845764 
  12. Lindh E, Lounela H, Ikonen N, Kantala T, Savolainen-Kopra C, Kauppinen A, et al. Highly pathogenic avian influenza A(H5N1) virus infection on multiple fur farms in the South and Central Ostrobothnia regions of Finland, July 2023. Euro Surveill. 2023;28(31):2300400.  https://doi.org/10.2807/1560-7917.ES.2023.28.31.2300400  PMID: 37535475 
  13. Shu Y, McCauley J. GISAID: Global initiative on sharing all influenza data - from vision to reality. Euro Surveill. 2017;22(13):30494.  https://doi.org/10.2807/1560-7917.ES.2017.22.13.30494  PMID: 28382917 
Highly pathogenic avian influenza A(H5N1) virus infection in foxes with PB2-M535I identified as a novel mammalian adaptation, Northern Ireland, July 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Paula+Lagan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lagan Paula</a>, <a href="/search?value1=Robyn+McKenna&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McKenna Robyn</a>, <a href="/search?value1=Salam+Baleed&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Baleed Salam</a>, <a href="/search?value1=Bob+Hanna&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hanna Bob</a>, <a href="/search?value1=Jason+Barley&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Barley Jason</a>, <a href="/search?value1=Shirley+McConnell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McConnell Shirley</a>, <a href="/search?value1=Anastasia+Georgaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Georgaki Anastasia</a>, <a href="/search?value1=Tarja+Sironen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sironen Tarja</a>, <a href="/search?value1=Ari+Kauppinen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kauppinen Ari</a>, <a href="/search?value1=Tuija+Gadd&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gadd Tuija</a>, <a href="/search?value1=Erika+Lindh&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lindh Erika</a>, <a href="/search?value1=Niina+Ikonen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ikonen Niina</a>, <a href="/search?value1=Michael+J+McMenamy&option1=author&noRedirect=true" class="nonDisambigAuthorLink">McMenamy Michael J</a>, <a href="/search?value1=Ken+Lemon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lemon Ken</a></span>. Highly pathogenic avian influenza A(H5N1) virus infection in foxes with PB2-M535I identified as a novel mammalian adaptation, Northern Ireland, July 2023. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(42):pii=2300526. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.42.2300526" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.42.2300526</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 04 Oct 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 17 Oct 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.42.2300526
/content/10.2807/1560-7917.ES.2023.28.42.2300526
Loading

Data & Media loading...

Supplementary data

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error